Crossword-Solution: UPPERS 6 letters, 31 clues 🏆 scrabble score: 10

It seems to me that no matter whether you marry, settle down or live with a bird or not, certain ones simply have your number on them, like bombs in the war; and even if you don’t happen to like them all that much there’s nothing you can do about it — unless you’re prepared to spend a lifetime arguing fate out of existence, which you could probably do if you tried but I’m not the type. — Crust on Its Uppers, p. 87

Fear triggers the fight-or-flight response, fueled by adrenaline, which, as it turns out, is chemically related to amphetamines. Granted, it's a very different kind of high for mindfuckers: not a mellow, floaty "my vulva is one with the universe" high but a jittery, revved-up "oh fuck oh fuck oh fuck" kind of high. Endorphins are like great downers but adrenaline is uppers all the way. And it's just as addictive. Don't believe me? Go ask anyone who likes to jump off bridges or out of airplanes. - Edge

We had two bags of grass, seventy-five pellets of mescaline, five sheets of high powered blotter acid, a salt shaker half full of cocaine, and a whole galaxy of multi-colored uppers, downers, screamers, laughers... and also a quart of tequila, a quart of rum, a case of Budweiser, a pint of raw ether and two dozen amyls. Not that we needed all that for the trip, but once you get locked into a serious drug collection, the tendency is to push it as far as you can.